When I first built my Cafe' conversion....I did what almost everyone else does and put a 100/90-18 tire on a 2.15" wide front rim, and a 130/70-18 rear tire on a 2.50" wide rear rim. It all appeared normal and rode fine....however it didn't take long for me to see that the tread on the rear tire was rolled over onto the sidewall....and a lot of tread was never going to be used no matter how far I leaned the bike over. The unused tread (chicken strip) on each side of my front tire appeared to be about 3/8", while the unused tread on the rear was closer to 3/4"! (If you look closely at the picture below you can see the width of the chicken strips, and how the tread profile on the rear tire rolls over onto the sidewall and doesn't match the front tire).

The center tread on the rear tire wore pretty quickly and I developed a wide flat spot in about 4,000 miles....about 2/3rd of the tread was gone in the middle while the sides were not worn. This was a bit of a surprise as I don't ride on straight roads much and corner pretty aggressively. As I began to look and see what tire options I had, I discovered that at 130/70-18 tire is not recommended or approved to be mounted on a 2.50" wide rim....it is supposed to be on a 3.50" wide rim and the narrowest rim it is recommended for is a 3.00".

So the next tire I ordered and used was a 110/80-18 rear tire. Before I took the 130 tire off the 2.50" rim I measured the width of the tire tread...and it was 116mm - the 110 tire width was 109mm when mounted. I also changed the front tire from the 100/90-18 to a 90/90-18 tire as it was a better size match for the smaller rear tire.
I rode on these tires for a couple of months last summer, and the smaller tires proved to be plenty of tire for the bike. The front tire cross section didn't change much and the tire was just a bit narrower and less tall, the rear tread cross section laid flatter to the road. I was able to get over to within 3/8" of the tire edge on both tires. The tires appeared just a bit skinny compared to what I was used to.....however they seem to be perfectly suited to the weight and HP of the bike.
Last winter I did some more changes, and I wanted to explore the 130/70-18 tire on a 3.50 rim where it is supposed to be. At the same time I decided to upgrade the front tire to a 100/80-18 for a bit more width. The change went fine....although it is hard to find a tube to fit a 100/80 tire...Heidenau is the only tube I could find in that size.
This year I have been riding on the larger tires for a couple of months including a Dragon trip a couple weeks ago. The tires work good and look OK...however the 3.50 wide rear rim and wide 130 tire have brought back a bit of the Cruiser look and less of the Vintage Road Racer look....old bikes don't have wide rear rims or tires!
I made some templates for the tire cross section/width, and here is what I found:
This sketch shows the comparison of the tires on the rims they are made to fit. The 110/80 tire is on a 2.50 rim and the 130/70 tire is on a 3.50 rim. The 110 tire has a tread width of 109mm and the 130 tire had a tread width of 128mm. You will note that the tread shape is almost identical.....it is designed to have this shape on the recommended rim width.

This is a comparison of the 130 tire mounted on the 2.50" rim and the 3.50 rim. You can see how the narrow 2.50 rim arches the tire out of the proper shape.

This sketch shows what the 130/70 tire looks like on a flat road surface, as well as on a 45 degree surface. A street bike will be hard pressed to obtain this lean angle - but note how close the edge of the tire is to the 45 degree line that represents the road in a hard turn.

This photo shows what happens when you squeeze a 130 tire onto a narrow 2.50 rim. The tire tread is arched and pulled away from the paving so that the tread touching the road has been narrowed. The tire on the 3.50 rim has 4.2 inches of tread that can touch the road between the 45 degree lines in both directions...this tire only has 3.8 inches between those lines (The 110 tire has 4.0 inches between those same 45 degree lines!). The difference might even be more as these profiles don't take into account the tread will flatten a bit when the weight is applied to the tire.

CONCLUSION - It is my belief that if you want the lightest and quickest Cafe' bike....you should go with a 90/90-18 front tire on a 2.15" rim and a 110/80-18 rear tire on a 2.50 rim.
If you want a bit beefier tire combination you can use the 90/90-18 front tire on a 2.15" or 2.50" wide rim.....You can also use the 100/80-18 tire on a 2.15" or 2.50" wide rim for a bit lower profile tire (although you will find that it is hard to get this size in some performance tires like the Battlax BT-45......they list it as being made but it doesn't seem to be imported into the US). For the rear tire you can use a 130/70-18 if you mount it on a 3.50" wide rear rim (or even a 3.00 rim if you can find one) - but squeezing this size tire onto a 2.50" rim will actually get you less rubber on the road than you will get with the narrower 110 tire.
FOR ME......at this point I am sticking with the 100/80-18 front tire. I am not sure which back tire/rim I am going to stick with....a summer of riding/testing is in progress!