Blue Ridge Mountains and Skyline Drive near Afton, VA if you wanna head over and then up...

Route 66 ... if you don't. I'll kill ya!

The Mississippi river road. Runs up and down the river from somewhere in Wisconsin, south through Iowa and so on. Scenic with some twisties and hills. Come up from the south, to the Wisconsin river, and then cut over to Madison, (state Capitol), and check out the Capitol building grand rotundra. If you time it right, (late August-early July), you can then go east to Milwaukee and check out Miller Park, where the Milwaukee Brewers play, then on to the art museum on Lake Michigan, right next to the Summerfest grounds. Midwest's largest summer music festival. Good times. If you have 3 hours left, then go north to Green Bay and see the hallowed grounds of Lambeau Feild, home of the defending Super Bowl Champion Packers. They have a tour where you see inside the playing field, and they have the Packers hall of fame. See the 4 Super Bowl trophies. Then cruise up into Door County, (the finger of Wisconsin) Lots of old world stuff to see, and very scenic. Or, head south to Chicago to see the Sears tower. A paid tour to the viewing deck on top is well worth the time and money. While in Wisconsin, stop and enjoy a delicious Culvers double cheeseburger.

If u go over then up The Cherohala Skyway Drive,Tail of the Dragon U.S. 129,Blue RidgeParkway and Skyline Drive as per First Reply.   Things to stop and see that i liked #1 Biltmore Mansion in Asheville N.C. #2 The Luray Caverns,GrandFather Mountain, and Mawbry Mill and Andy Griffiths home town Mount Airy.

The Black Hills are indeed some great scenery. Carhenge is cool too, used to drive by it every couple weeks going to and from college.

If ya get to the Northwest area, I recommend the Columbia River Gorge, either Oregon or Washington sides.

I agree there too. I have been to Estes Park several times on vacation. Ride the tram up the mountain. Awesome. Going East through Big Thompson canyon would be a rush on a bike. The Royal Gorge Bridge, down by the Military base there, is a sight to see. Highest suspension bridge in the USA, I believe. Further east you got the black hills, the badlands, Sturgis, mount Rushmore, Crazyhorse. Plenty to see. Nebraska and Iowa are pretty boring, (miles and miles and miles of nothing but corn), but don't forget Wisconsin. The northern 1/2 of the state is very scenic. Nicolet National Forest. Door county. (Egg Harbor fish boil. yumyum)  Awesome.