I am in East/central Oklahoma just above you a little and I used a 52.5 pilot on a stock bike with a Dyna  muffler and both stock and pod filter and they worked great.
There is no problem trying a 50 pilot and if you just want to see how it will run.  But before you do that what is the current setting for your pilot screw ?  Is it between 1 & 2 turns out ?  With the correct pilot you should be in that range.  Is your pilot screw setting giving you the highest rpm while tuning it ?  This assumes the engine is completely warmed up before tuning; at least 10 minutes idling or ride for 2-3 mi.  Bike must be vertical for sustained idling to protect cam bearing oil supply.

Thanks! Sticking with the #52.5 pilot for now. I'll get it buttoned up and see where the mix screw falls.

.the pilot makes a big difference in MPG's

Did na knoe that..Thot the main jet was the main culprit,,

If you are a 70+mph distance cruiser, it probably doesn't make a huge difference,... but our bike is generally a putter, not a road eater.
A lot of my riding is relaxed 30 to 50mph on slow windy roads or in town and I'm barely on the throttle.
... but also consider, when you are starting to draw the majority of fuel from the slide,.. the pilot is still open and using fuel... It's running at all speeds above idle.

Plus,... my pilot/mpg info came from a Mikuni manual I read once, a long time ago, not my tiny brain... so I'll just go with it to make myself sound clever...