Not usually.Depends on the tire and the bike.I run 150s on all of my bikes.With the stock fender I had to slot the mounting holes about 1/4".The fender was not truly centered.AND use button head bolts in case the tire makes contact with them.One of my builds,Suzuki was off and I had to trim about 1/4 - 1/2" out of the crossbrace on the swingarm.
First pic is the one I had to oval mounting holes.Second is the one I had to trim swingarm.