The slide is controlled by engine vacuum.... steady state cruising at speeds under 60mph or so, give very high vacuum, so there's not much slide action... you should be running mostly on the pilot jet...
Slide is mostly active on acceleration... or WFO...
...it's pretty much a metering rod for the main jet...not really a separate system... once it's at zero vacuum, it's out of the way and the main is clear...
The pilot jet has the biggest effect on mileage, if you're a mileage junkie...
If you're a squid,... that's a whole 'nuther story...
Jets don't really react according to a bikes speed,... they react to engine vacuum...