With the throw over type of bags, I'd say the only problems you could run into would be the turn signals getting in the way if the bags are too big. And where to tie them down. Both problems are easy to figure out. I've done the turn signal relocation
That worked okay but the LED lights that I used were almost invisible during the day. Thats when I went with the hard bags with built in turn signals. That was a good Idea but the built in turn signals were also LED and also very hard to see. So I added a set or standard turn signals to the hard bags
Now I'm happy with the bags and turn signals. I also changed the brakelight for a cats eye. Now if I could just find the right seat...........