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Message started by eau de sauvage on 04/23/20 at 04:10:10

Title: Surprise hydroxychloroquine is bs. Who knew?
Post by eau de sauvage on 04/23/20 at 04:10:10

Who could ever have guessed that hydroxychloroquine was utter bs, er everyone except the bs master in chief. As if it was going to work. But what did Trump and his little mouthpieces on these forums say, 'oh it can't hurt'.

Er think again...but in the past week or so, Trump has all but stopped talking about hydroxychloroquine. And so have Fox News’s hosts.

The relative silence follows disappointing, even alarming, new research about hydroxychloroquine as a treatment for covid-19, the disease caused by the virus. A study released this week on 368 male Veterans Affairs patients with the disease showed that the death rate among those given the drug, both in combination with another drug and alone, was higher than for those who were not.


https://www.washingtonpost.com/lifestyle/media/fox-news-hosts-go-mum-on-hydroxychloroquine-the-covid-19-drug-they-spent-weeks-promoting/2020/04/22/eeaf90c2-84ac-11ea-ae26-989cfce1c7c7_story.html

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 05:53:46

Wow - what a spin -

Even as recently as 12 days ago - India disagrees with you.

https://www.forbes.com/sites/anuraghunathan/2020/04/09/indias-drugmakers-ramp-up-production-of-game-changer-coronavirus-drug-hydroxychloroquine/#2f2257d35d5a

9 days ago.

Even as chloroquine shows potential for treating COVID-19, doctors warn caution needed

https://abc7.com/health/doctors-say-caution-needed-in-drug-treatment-for-covid-19/6082485/

Its just that recently Remdesevir has taken a better route to getting approval etc. The death rate etc etc needs to be matched to severity and how well the patients were otherwise, and since no clinical trials were done its not an easy conclusion to make.

This is why remdesevir is popular as a research tool and for trials etc etc - Its still under patent. Its pricey and hence options to make a lot more $$$. Its now the flavor of the month.

This CNN story is right as accurate as claiming the guy in Arizona who took pool cleaner cos its chloroquine phosphate as a fatality due to HCQ. Spin and garbage.

BTW the first pharma company to file a remdesevir alternate use patent was a pharma company from china - definitely China needs to be nuclear bombed.

Let me talk to my people in India about what they're doing with HCQ and how effective it is etc. HCQ is a very inexpensive drug. That alone is reason to not "research" it for big pharma.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by oldNslow on 04/23/20 at 06:31:50

Read the actual VA study. It's crap. The people they gave the drug to were already almost dead. If you wanted to select a cohort of patients that the drug had almost no chance of helping that's exactly how you would do it.

But of course our friend from down under  dosen't care about that."Trumps wrong. The US sucks. All you fookin' Yanks are gonna die."
Yada Yada Yada.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 07:17:20


3A283C3F282E2C490 wrote:
Who could ever have guessed that hydroxychloroquine was utter bs, er everyone except the bs master in chief. As if it was going to work. But what did Trump and his little mouthpieces on these forums say, 'oh it can't hurt'.

Er think again...[color=#8B0000]but in the past week or so, Trump has all but stopped talking about hydroxychloroquine. And so have Fox News’s hosts.
The relative silence follows disappointing, even alarming, new research about hydroxychloroquine as a treatment for covid-19, the disease caused by the virus. A study released this week on 368 male Veterans Affairs patients with the disease showed that the death rate among those given the drug, both in combination with another drug and alone, was higher than for those who were not.[/color]


https://www.washingtonpost.com/lifestyle/media/fox-news-hosts-go-mum-on-hydroxychloroquine-the-covid-19-drug-they-spent-weeks-promoting/2020/04/22/eeaf90c2-84ac-11ea-ae26-989cfce1c7c7_story.html




Oooooo shocking - that's a pay site. Simply shocking.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 07:38:38

HCQ apparently is not recommended for long periods due to being associated with amnesia like symptoms - which often wipe out the entire duration they are taking the medication. Usually this happens with foreigners who live in India for extended periods of time and are on HCQ to prevent Malaria. If they spent 2 yrs in India and was on it for 3 months prior, at some point in that 2 yrs - say 1.5yrs in - they forget that entire time frame.
Of late there has been cardiac arrest cases on it also because I believe this is a higher dose than the malaria prevention dose used for a shorter time.
China built a good virus guys. A darn good one.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by justin_o_guy2 on 04/23/20 at 08:17:23

Nobody just pulled the idea for that medication out theysDumbAss,, Doctors saw test results and figured out that people who were ill and Using this medication, Didnt GET the ViRuss,,,Theres a couple of reasons that medication is prescribed, not exactly rare problems,, I Wish I could remember them now..

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/23/20 at 08:37:01


 Well the reason its found in so many elderly is because its used for arthritus treatment.  Its used as a antirheumatologic agent in rheumatoid arthritis and systemic lupus erythematosis.

 C18H26ClN3O structurally is an immunosuppressive, so I still think it would be surprising to see it used as a SARS treatment.  

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 08:53:03


58787A726F781D0 wrote:
 Well the reason its found in so many elderly is because its used for arthritus treatment.  Its used as a antirheumatologic agent in rheumatoid arthritis and systemic lupus erythematosis.

 C18H26ClN3O structurally is an immunosuppressive, so I still think it would be surprising to see it used as a SARS treatment.  




Then how is it used and has for decades been very very well researched and effective as a malaria treatment ????

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 10:12:20

And remdesevir crashes and burns - leaving - well - bupkis.
HCQ has been used well enough in India, cheap enough cos India is flooding the market.
Once again - china has created a good one, darn good one.
If only they made other shitttete with this type of ingenuity and dedication … we don't have to buy new crap every 2-3 months.

Maybe I should capture some of this virus and stuff it into my headlight mounting holes, cos those threads in chintzy a$$ sheet metal have crapped out with 2-3 test fittings.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by MnSpring on 04/23/20 at 12:14:24


30312A2D22372B430 wrote:
" ... Then how is it used and has for decades been very very well researched and effective as a malaria treatment ???? ..."

Chloroquine is a replacement for Quinine Sulfate (Replaced in the late 20’s because it was much better without many of the former's side affects) Quinine Sulfate was still around and could be gotten for various sources.

I know this because Quinine Sulfate was routinely used, sold, and passed around, in the world I was highly involved in for over 25 years.
It was used for Leg Cramps.  The ’regular dose’, was to be 2, 300mg tablets, (600mg), every 8 hours for malaria.
The people using it for Leg Cramps, (after walking in a field all day), took 1/4, or 1/8th of one pill.
A dose of 75 to 35 mg, Once for 24 to 48 hours.

If I was very sick with C-19, and someone said here try this drug, it has helped many others.
I would not listen to UL, DFI, FDS, Socialists, who would say:
“No you MUST pay MORE, so I, can make MORE !"


Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/23/20 at 12:20:05

Thanks Mnspring.

But I'm trying to find a way to harness the Chinese power of this virus to fix all the other Chinese chitte that's broken after 1/100th the intended use.

If only this virus was like a nano particle. Tell it to fix the threads that were chewed up in this Chinese headlight … and drop a spoon of it here and there. They should find their spot and "weld up" onto the threads.

Afterall it seems to be programmed to resist everything and claw and eat till death do us part.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by eau de sauvage on 04/23/20 at 14:28:39

Trump didn't like Merkel and refused to shake her hand at a press conference in the WH, understandable really considering she is a woman and also a trained physicist. Too smart by half. But he loved the bs reception he got in France. Now Germany's fast response and trust in their their health officials has overseen a "textbook" response to the Corona virus, whereas France has completely borked their response much as the USA did under Trump so is it any wonder that now we see this...

"The study at a major Paris hospital suggests a substance in tobacco – possibly nicotine – may be stopping patients who smoke from catching Covid-19. Clinical trials of nicotine patches are awaiting the approval of the country’s health authorities."

https://www.theguardian.com/world/2020/apr/22/french-study-suggests-smokers-at-lower-risk-of-getting-coronavirus


Expect Trump to be touting nicotine patches tomorrow.

Germany has shown the US the difference between an antiscientific populist bs response like France and what could have been done. Look at the figures for France, Spain, and Italy, as opposed to Germany. All geographically, bunched together with similar technical prowess and wealth.

The US, the ones who put together a uranium and a plutonium bomb at the bleeding edge of known science at the time, have plummeted in their ability to do stuff when it's really needed. Fcuk they can't even get their freaking testing organised. And Trump talks about sh!thole countries, and making America great again. The showman and his slogans.

A true leader of any organisation, is not expected to know everything about everything, but he is expected to know how to find and recognise the top people who do know and to bring them on board. However way of leading is  anathema to a clinical narcissist like Trump.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by eau de sauvage on 04/23/20 at 14:55:31

But wait, there's more...

Further to my previous comment about a leader being able to select the right people, Trump does the exact opposite, this is like Bizarro USA, he ridicules his top expert and sacks him.

https://www.newyorker.com/news/daily-comment/trumps-firing-of-a-top-infectious-disease-expert-endangers-us-all

Gellin told me, “Rick was able to advance our national pandemic preparedness for drugs, diagnostics, and vaccines,” adding, “He knows the science and embraces cutting-edge technology like few others.’’ Margaret A. Hamburg, who was the commissioner of the Food and Drug Administration under President Barack Obama, also worked closely with Bright. “This is hard to understand,’’ she said. “Rick is exactly the person you want to have at the table when planning new programs, especially in the midst of a pandemic.’’



Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/23/20 at 16:14:16

"Then how is it used and has for decades been very very well researched and effective as a malaria treatment ???? "


 I never said it wasn't.  However when taking it to prevent malaria one can have side effects, like any drug, one of them being it's immunosuppressive properties.

 I very specifically said "found in so many elderly" in an attempt to indicate that it is found in the US population among humans age 65 1/2 and older.

 This is not because they are concerned with catching malaria.  It is because it is used in the treatment of arthritis and similar.  This includes side effects, including immunosuppressive ones.  

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/24/20 at 06:27:38


0020222A3720450 wrote:
"Then how is it used and has for decades been very very well researched and effective as a malaria treatment ???? "


I never said it wasn't.  However when taking it to prevent malaria one can have side effects, like any drug, one of them being it's immunosuppressive properties.

 I very specifically said "found in so many elderly" in an attempt to indicate that it is found in the US population among humans age 65 1/2 and older.

 This is not because they are concerned with catching malaria.  It is because it is used in the treatment of arthritis and similar.  This includes side effects, including immunosuppressive ones.  




Once again you're talking in circles. Its used to fight off infections. It may be a immunosuppressant if you're not infected with something maybe - Or maybe Rheumatoid arthritis is a hyper active immune system that needs to be suppressed - I don't know. Neither of us are doctors as far as I know. But its a safe, cheap, mass produced drug and as it stands our best bet till other research is done. Remdesevir has failed and that ends the best $$$$ making option.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/24/20 at 06:36:00


61736764737577120 wrote:
Now Germany's fast response and trust in their their health officials has overseen a "textbook" response to the Corona virus, whereas France has completely borked their response much as the USA did under Trump so is it any wonder that now we see this...



Germany is something else. Their discipline is something else, as is the fact they have the least amount of Chinese immigrants, Germany also has the most well funded and well built health system cos they didn't have massive influx like Italy and France, or even England did.
Italy and France are both undisciplined and have high amount of Chinese, including Italy which had "hug a Chinese person day" etc.

How are the rates in Sweden. I'll Bet they're near about Germany because they naturally practice social distancing.

BTW I find a lot of news from Australia, how they're fed up of Chinese etc etc, I take it that you're disagreeing with them as well ?

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by justin_o_guy2 on 04/24/20 at 07:16:07

Yea, yeah, Trump, racist, sexist, Bullshit.
He hired the first female engineer to build a high rise.
Merkel is one sorry person. Trump, if in fact he didn't shake her hand, didn't make that choice because she's a woman or he feels intimidated by her genius,, he made that choice for reasons that you won't understand.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/24/20 at 09:54:11


283731362B2C1D2D1D25373B70420 wrote:
Yea, yeah, Trump, racist, sexist, Bullshit.
He hired the first female engineer to build a high rise.
Merkel is one sorry person. Trump, if in fact he didn't shake her hand, didn't make that choice because she's a woman or he feels intimidated by her genius,, he made that choice for reasons that you won't understand.





LOL, BTW have you heard Merkel speak ???
It really sounds like someone speaking a made up language - almost like froooshen fuynkoen shooshen vrroooshen schinken schwieonken etc etc … Obviously I don't know german - Except Ich Weis Nicht.

German sounds much more hard edged and more precise - I've heard others speak it. In a way its similar to Tamil my native tongue. It follows Hindi/Sanskrit like grammer - which Tamil is the polar opposite of, but Tamil is all hard edges and words that sound like a hammer. It is not a pleasant language - definitely not musical like French. But Merkel has a French sounding approach to german and it sounds like she's speaking a made up language full of whooshes and swooshes. Or maybe she's always speaking with a mouthful of bratwurst and beer.

German to English is like Tamil to Kannada (another Indian language which lifted the script from Telugu and grammar from tamil and made up the words). Grammar is close, words are all different. Non musical to semi musical. Parallel language swaps.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/27/20 at 06:50:41


61736764737577120 wrote:
Who could ever have guessed that hydroxychloroquine was utter bs, er everyone except the bs master in chief. As if it was going to work. But what did Trump and his little mouthpieces on these forums say, 'oh it can't hurt'.

Er think again...but in the past week or so, Trump has all but stopped talking about hydroxychloroquine. And so have Fox News’s hosts.

The relative silence follows disappointing, even alarming, new research about hydroxychloroquine as a treatment for covid-19, the disease caused by the virus. A study released this week on 368 male Veterans Affairs patients with the disease showed that the death rate among those given the drug, both in combination with another drug and alone, was higher than for those who were not.


https://www.washingtonpost.com/lifestyle/media/fox-news-hosts-go-mum-on-hydroxychloroquine-the-covid-19-drug-they-spent-weeks-promoting/2020/04/22/eeaf90c2-84ac-11ea-ae26-989cfce1c7c7_story.html




I finally saw this video. The study is bogus bullcrappe.
The study is not a blind controlled trial - the standard required for being even submittable for peer review - which this wasn't.
The fatality rates etc etc are not indexed to severity and the study was from random after the fact deaths. In fact the ones not on HCQ were the least severe and the HCQ+az were the most severe. Those 2 being so close really is telling that that combo worked a lot better.
Then the biggest kicker is -
The fools who did this have no idea who HCQ works. This is as stupid as you trying to hammer a nail in the wall using your motorcycle  to bash it in, and then complaining that the wall has caved and its the motorcycles fault.

HCQ is a zinc into the cell transport enhancer.
Zinc kills off the virus's ability to replicate.
To get zinc to be more effective, the additional supplements are Vitamin D, vitamin C etc.
Azithromycin is an antibiotic, helps a little more effective killing of germs.
HCQ needs vit D, Vit C and most importantly zinc to do anything. Azithromycin is just a killer, get it into where the virus is, it kills that, else it will kill bacteria in your digestive tract. This will not work without zinc. No zinc was given - end of story. Bad study with dead people conducted bass ackwards.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/27/20 at 09:40:53


"Zinc kills off the virus's ability to replicate."

 I know of two locations that are evaluating this.  So far it is not conclusive.  Seven 40 - 45 year old's, with no known underlying health issues did show viral replication/spread.  

 Super small case study though, but percentage wise it hits the Zinc curve pretty hard.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by pg on 04/27/20 at 11:57:59

I say the CDC is in the pocket of big pharma.  They should have been instructing people to take vitamin c, vitamin d, and zinc from the start.  This is simply to strengthen the immune system.

Best regards,

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/27/20 at 13:51:07


79595B534E593C0 wrote:
"Zinc kills off the virus's ability to replicate."

 I know of two locations that are evaluating this.  So far it is not conclusive.  Seven 40 - 45 year old's, with no known underlying health issues did show viral replication/spread.  

 Super small case study though, but percentage wise it hits the Zinc curve pretty hard.






Ooooo Eegore - how fast can you back pedal out of the "Surprise hydroxychloroquine is bs. Who knew?" … Title of this thread.

This is medical, organic and nothing ever has a clear cut off line. …
Making a little bit of $$$ off my remdesevir stock is fine for me … time to get rid of that 5% of my portfolio, that crap is cooked. But really, china virus is powerful beyond belief.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/27/20 at 17:30:01


"Ooooo Eegore - how fast can you back pedal out of the "Surprise hydroxychloroquine is bs. Who knew?" … Title of this thread."

 What are you talking about?

 In what capacity is stating I am aware of a zinc inclusive testing trial "back pedaling"?  It's zinc and hydroxychloroquine.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/28/20 at 06:18:11


78585A524F583D0 wrote:
"Zinc kills off the virus's ability to replicate."

 I know of two locations that are evaluating this.  So far it is not conclusive.  Seven 40 - 45 year old's, with no known underlying health issues did show viral replication/spread.  

 Super small case study though, but percentage wise it hits the Zinc curve pretty hard.



So you're rather slickly sliding from - "Surprise hydroxychloroquine is bs. Who knew ?" - To hitting the curve pretty hard ??? in an ongoing study. Just smooth and slick like some of your heroes. Clinton, Biden, Obama ?
You should consider a career in politics.

Cos in science its worthless, because, the study first would have to be designed - the design peer reviewed and the treatment performed under double blind and the results before publishing peer reviewed again. Hitting the curve pretty hard - may be total BS just like the first study. But dont let any of these facts take away from the slick willyiness.
Its time to accept defeat - for both of us. China accidentally or intentionally designed and spread a good one. The HCQ may be the best bet so far to save people who might otherwise be dead - or its not as good as the "other" treatments. No idea, more research controlling for all variations and conditions should be done. This is sort of a slow slow process, and we're field testing a medication because the disease is killing faster than our process of testing this or other drug for this or that.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/28/20 at 11:16:40


 I don't care what the politics are.

 I am just saying that since zinc inclusion studies are so small, even having just a few report no improvement has a higher percentage impact than a larger patient pool.

 Just basic math.
 

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/28/20 at 14:07:50


6040424A5740250 wrote:
 I don't care what the politics are.

 I am just saying that since zinc inclusion studies are so small, even having just a few report no improvement has a higher percentage impact than a larger patient pool.

 Just basic math.
 



Really slick willy -
For the basic math part - how about trying to define deaths per capita - and that is not even counting the ridiculous population density or the green city busses and riding trains with 300,000 of your closet friends ...

Tk about talking out of both sides of your mouth and A$$.

Now china has spread a darn fine virus. A real real doozy.

Maybe HCQ and zinc and vit D and C and azithromycin makes for better outcomes in equally bad patients, but then that crap is in short supply, only the well connected or the about to die get HCQ - your own link says so - sadly, its the best we got, cos china didn;t give us the advance notice they had leaving US in the dark while the WHO pandered to the chinese.

Since that's the strategy around teh virus - I guess more of the US populace dying just proves their strategy.aToo bad the dying are in heavily democrap areas, but no issues, the dead vote reliably democrat and if they dont, all the rest of their neighbors do, so it makes no difference, thank to electoral college.

In any case, yourve golne from BS to maybe its no as effective in 2 posts. Good luck with your political career. Just get a clinton or a Obama to endorse you, you got it made in the shade and fat chicks far as the eye can see.

Cool.
Srinath.

Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by Eegore on 04/28/20 at 16:38:25

"In any case, yourve golne from BS to maybe its no as effective in 2 posts."

 I made no claims either way.  I said there is a reason it is found in elderly patients.  Arthritis.  For some reason you want to complain about that, but that won't make it less true.  Hydroxychloroquine is found in elderly patients with arthritis, and they all have to be weary of side-effects, like any other drug ever.


 Then I said that the zinc inclusionary trials, I am aware of, are small so the seven people that showed continued presence, and growth of SARS-COV-2 hit that trial percentage hard because the zinc inclusionary trials, I am aware of, are small in number.  For some reason you want to complain about that, but it won't change the fact that zinc inclusionary trials, that I am aware of, are small in number.

 That's it.  I said old-people have hydroxychloroquine in their systems and that zinc inclusionary trials, that I am aware of, are small in number.


Title: Re: Surprise hydroxychloroquine is bs. Who knew?
Post by srinath on 04/28/20 at 17:33:07

Eegore - You didn't start this post - EDS did. Except my work laptop was a disaster when I was posting - chewing up my posts as well as logging me off 10 times in each post.

We're fighting an awesome china virus with zip ties, duct tape and inner tube.
You feel free to argue your bicycle inner tube is better than my car inner tube - all day - no worries. ALL I CAN SAY - this is the best we can scare up as of today.

Cool.
Srinath.

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